rs11731496 - GC - NPFFR2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry. - The American journal of clinical nutrition (2023) · Parlato LA, Welch R, Ong IM, Long J, Cai Q, Steinwandel MD, Blot WJ, Zheng W, Warren Andersen S · PubMed 36811574

  Vitamin D deficiency is more common among African-ancestry individuals and may be associated with adverse health outcomes. Vitamin D binding protein (VDBP) regulates concentrations of biologically active vitamin D. We conducted genome-wide association study (GWAS) of VDBP and 25-hydroxyvitamin D among African-ancestry individuals. Data were collected from 2,602 African American adults from the Southern Community Cohort Study (SCCS) and 6,934 African- or Caribbean-ancestry adults from the UK Biobank. Serum VDBP concentrations were available only in the SCCS and were measured by using the Polyclonal Human VDBP ELISA kit. Serum 25-hydroxyvitamin D concentrations for both study samples were measured by using Diasorin Liason, a chemiluminescent immunoassay. Participants were genotyped for singl

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