Expressive

rs11730384 - TSPAN5

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • TSPAN5 genetic insomnia risk with healthcare provider Moderate

    GWAS evidence (n=2.3M, p<1e-9) associates this variant with insomnia; medical evaluation determines if genetic predisposition is clinically manifesting

Lifestyle

  • sleep hygiene optimization protocol Moderate

    Consistent sleep optimization may help offset genetic predisposition to insomnia; TSPAN5 cerebellar function affects sleep regulation

    Consistent bedtime/wake time; dark, cool room; no screens 1hr before bed; limit caffeine after 2pm

Screening

  • sleep quality and insomnia assessment Moderate

    TSPAN5 rs11730384 is associated with insomnia in large-scale GWAS; variant carriers show increased insomnia risk

    Track sleep quality weekly; consider validated insomnia screening (e.g., Pittsburgh Sleep Quality Index)