Expressive

rs11729628 - MAD2L1-DT - PRDM5

Magnitude 2.2 · 1 study on file

Reported associations

  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations - Unknown journal (n.d.) · Unknown authors · PubMed 34450027

    ABSTRACT: Summary Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic c

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Low-impact aerobic exercise Moderate

    Regular low-impact activity supports cartilage health and joint stability without excessive mechanical stress

    Aim for 150 minutes moderate-intensity aerobic activity weekly, low-impact options like swimming or cycling

Lifestyle

  • Body mass index for joint health Moderate

    Osteoarthritis is genetically correlated with elevated BMI; weight management reduces joint loading and cartilage stress

    Maintain BMI in normal range (18.5-24.9 kg/m2); discuss weight management with healthcare provider

Screening

  • Osteoarthritis symptoms and joint health Moderate

    This variant is associated with osteoarthritis susceptibility; early monitoring enables early intervention for joint health

    Annual joint health assessment including symptom review; earlier if joint pain develops