rs117295690 - HEMK1
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Unknown journal (n.d.) · Unknown authors · PubMed 40465716
ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Type 2 diabetes risk stratification and prevention plan Moderate
Genetic association with Type 2 diabetes warrants clinical assessment and individualized prevention strategy.
Screening
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blood glucose and hemoglobin A1C Moderate
rs117295690 is associated with increased Type 2 diabetes risk; routine monitoring enables early detection.
Fasting glucose and A1C testing annually starting at age 25, or sooner with family history.