Expressive

rs117273720 - PSD2

Magnitude 4.5 · 1 study on file

Reported associations

  • A genome‐wide association meta‐analysis of all‐cause and vascular dementia - Unknown journal (n.d.) · Unknown authors · PubMed 39046104

    ABSTRACT: Abstract INTRODUCTION Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome‐wide association studies (GWAS) focus on AD. METHODS We conducted a GWAS of all‐cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonanc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean diet pattern Moderate

    Mediterranean diet has strong evidence for cardiovascular and cognitive protection; particularly relevant for vascular dementia prevention.

    Follow Mediterranean dietary pattern: emphasis on vegetables, fruits, whole grains, olive oil, fish, legumes

Exercise

  • Regular cardiovascular exercise Moderate

    Vascular dementia results from reduced cerebral blood flow; maintained cardiovascular fitness preserves vascular function.

    150 minutes moderate-intensity aerobic activity per week

Screening

  • Blood pressure monitoring and control Moderate

    Hypertension is a major modifiable risk factor for vascular dementia; genetic predisposition warrants heightened attention to vascular risk factors.

    Check blood pressure regularly; maintain systolic <130 mmHg if possible

  • Cognitive screening and monitoring Moderate

    Strong genetic association with vascular dementia suggests elevated risk; early detection enables intervention.

    Baseline cognitive assessment by age 50-60 if homozygous risk, age 60-65 if heterozygous; repeat every 3-5 years