rs117271698 - LNCAROD

Magnitude 2.2 · 1 study on file

Reported associations

• Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging - Unknown journal (n.d.) · Unknown authors · PubMed 39144724

  ABSTRACT: Introduction: Vitamin C is an essential nutrient. Sex differences in serum vitamin C concentrations have been observed but are not fully known. Investigation of levels of metabolites may help shed light on how dietary and other environmental exposures interact with molecular processes. O-methylascorbate and ascorbic acid 2-sulfate are two metabolites in the vitamin C metabolic pathway. Past research has found genetic factors that influence the levels of these two metabolites. Therefore, we investigated possible effect modification by sex of genetic variant-metabolite associations and characterized the biological function of these interactions. Methods: We included individuals of European descent from the Canadian Longitudinal Study on Aging with available genetic and metabolic da

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