rs117269052 - CDIP1
Magnitude 4.5 · 1 study on file
Reported associations
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Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort. - Endocrine (2021) · Yao Y, Chu X, Ma M, Ye J, Wen Y, Li P, Cheng B, Cheng S, Zhang L, Liu L, Qi X, Liang C, Kafle OP, Wu C, Wang S, Wang X, Ning Y, Zhang F · PubMed 34046847
Serum urate is associated with BMD and may be a protective factor. However, the exact association and mechanism are still unclear. We performed a genome-wide gene-environmental interaction study (GWGEIS) to explore the interaction effects between gene and urate on BMD, using data from the UK Biobank cohort. A total of 4575 participants for femur total BMD, 4561 participants for L1-L4 BMD, and 237799 participants for heel BMD were included in the present study. Linear regression models were used to test for associations between urate and BMD (femur total BMD, L1-L4 BMD, heel BMD) by R software. GWGEIS was conducted by PLINK 2.0 using a generalize linear model, adjusted for age, sex, weight, smoking behavior, drinking behavior, physical activity and 10 principle components for population str
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum urate levels Moderate
rs117269052 shows significant interaction with serum urate levels in relation to bone mineral density
annual serum urate testing
Discuss with your doctor
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bone and metabolic health management Moderate
Variant interaction with both bone mineral density and uric acid metabolism suggests coordinated assessment may be warranted
Screening
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bone mineral density screening Moderate
Variant interacts significantly with femur bone mineral density and serum urate levels
DXA scan if age 40 or older or other osteoporosis risk factors present