Expressive

rs11726091 - RN7SKP113 - CYTL1

Magnitude 2.8 · 1 study on file

Reported associations

  • Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study - Unknown journal (n.d.) · Unknown authors · PubMed 35448080

    ABSTRACT: The renin-angiotensin system (RAS) is a crucial regulator of vascular resistance and blood volume in the body. This study aimed to examine the genetic predisposition of the plasma renin concentration influencing future hypertension incidence. Based on the Korean Genome and Epidemiology Cohort dataset, 5211 normotensive individuals at enrollment were observed over 12 years, categorized into the low-renin and high-renin groups. We conducted genome-wide association studies for the total, low-renin, and high-renin groups. Among the significant SNPs, the lead SNPs of each locus were focused on for further interpretation. The effect of genotypes was determined by logistic regression analysis between controls and new-onset hypertension, after adjusting for potential confounding variable

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • sodium restriction Moderate

    RAS-dependent hypertension in high-renin individuals responds to sodium intake; the study emphasizes sodium modulation in this phenotype

    Limit sodium to <2300mg daily; adjust based on renin levels and blood pressure response

Exercise

  • regular aerobic exercise Moderate

    Aerobic activity reduces blood pressure and modulates renin-angiotensin system; critical in high-renin individuals where RAS activation drives hypertension risk

    150 minutes per week moderate-intensity aerobic exercise or equivalent

Lifestyle

  • weight management and BMI maintenance Moderate

    SNP associated with higher BMI in prior GWAS; excess weight amplifies hypertension risk particularly in RAS-dependent pathways

    Achieve and maintain BMI 18.5-24.9 through diet and physical activity

Screening

  • blood pressure and cardiovascular status High

    rs11726091 C allele strongly associated with new-onset hypertension in high-renin individuals (OR=1.48, p=4.2e-6) via altered MSX1 expression in vascular tissue

    Annual BP screening; baseline renin and electrolyte panel