Expressive

rs11725861 - LNX1 - RPL21P44

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878

    ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit sodium intake Moderate

    dietary sodium reduction lowers blood pressure and reduces cardiovascular strain

    aim for less than 2300mg sodium daily

Exercise

  • aerobic exercise for cardiovascular health Moderate

    aerobic exercise reduces pulse pressure and cardiovascular risk

    150 minutes moderate-intensity aerobic activity weekly

Screening

  • pulse pressure assessment Moderate

    rs11725861-A allele is associated with elevated pulse pressure, a cardiovascular risk marker

    assess pulse pressure annually