rs117252984 - HVCN1, TCTN1
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608
ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to elevated diastolic blood pressure Moderate
GWAS evidence suggests rs117252984 T allele is associated with higher diastolic BP; discuss individualized prevention strategy
Screening
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diastolic blood pressure screening High
Genetic variant in HVCN1/TCTN1 associated with increased diastolic blood pressure across 1.2 million individuals
Baseline measurement and annual follow-up; more frequently if elevated