rs117247077 - KMT5B - C11orf24
Magnitude 2.2 · 1 study on file
Reported associations
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Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels - Unknown journal (n.d.) · Unknown authors · PubMed 31578528
ABSTRACT: Elevated serum urate levels cause gout and correlate with cardio-metabolic diseases via poorly understood mechanisms. We performed a trans-ethnic genome-wide association study of serum urate among 457,690 individuals, identifying 183 loci (147 novel) that improve prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardio-metabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci, and co-localization with gene expression in 47 tissues implicated kidney and liver as main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in liver and kidney, HNF1
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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high-fructose beverages Moderate
Fructose metabolism increases uric acid production; avoiding high-fructose products is important for urate management
limit soft drinks, fruit juices, and foods with added fructose
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high-purine foods Moderate
Dietary purines are converted to uric acid; reducing purine-rich foods is the primary dietary intervention for managing elevated urate
limit red meat and organ meats to 1-2 servings weekly
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limiting alcohol intake, especially beer Moderate
Alcohol increases uric acid production and reduces renal clearance; limiting intake helps prevent elevated urate
minimize beer; limit other alcohol to moderate guidelines
Exercise
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regular physical activity Moderate
Obesity is associated with elevated uric acid; maintaining healthy weight through exercise helps prevent urate accumulation
150 minutes moderate aerobic activity weekly, strength training 2x weekly
Lifestyle
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adequate daily fluid intake Moderate
Sufficient hydration promotes renal uric acid excretion; adequate fluid intake helps prevent urate accumulation
8-10 glasses water daily; increase with exercise
Screening
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serum urate levels Moderate
This variant is strongly associated with elevated uric acid levels; regular monitoring helps detect high urate before gout or other complications develop
annually or per clinical recommendation