Expressive

rs117246401 - RPL7AP67 - ZNF24TR

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study - Unknown journal (n.d.) · Unknown authors · PubMed 35448080

    ABSTRACT: The renin-angiotensin system (RAS) is a crucial regulator of vascular resistance and blood volume in the body. This study aimed to examine the genetic predisposition of the plasma renin concentration influencing future hypertension incidence. Based on the Korean Genome and Epidemiology Cohort dataset, 5211 normotensive individuals at enrollment were observed over 12 years, categorized into the low-renin and high-renin groups. We conducted genome-wide association studies for the total, low-renin, and high-renin groups. Among the significant SNPs, the lead SNPs of each locus were focused on for further interpretation. The effect of genotypes was determined by logistic regression analysis between controls and new-onset hypertension, after adjusting for potential confounding variable

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • sodium intake Moderate

    This variant associates with sodium-sensitive hypertension via renin-angiotensin system dysfunction; higher sodium intake increases risk in carriers

    Maintain sodium intake under 2300 mg daily per standard hypertension guidelines

Discuss with your doctor

  • plasma renin concentration and hypertension risk Moderate

    Hypertension risk with this variant is substantially higher in low-renin versus high-renin individuals; measurement enables personalized risk assessment

    Request plasma renin concentration; discuss sodium restriction and potential ACE-I or ARB use based on renin status

Screening

  • blood pressure Moderate

    rs117246401 T allele increases new-onset hypertension risk 1.71-fold in prospective 12-year follow-up

    Annual blood pressure assessment; consider starting at age 30-35