rs117246187 - RIPOR3

Magnitude 4.5 · 1 study on file

Reported associations

• Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation and plasma lipids in the Health and Retirement Study. - Unknown journal (n.d.) · Unknown authors · PubMed 31201950

  ABSTRACT: Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's Disease risk variants. We examined pleiotropic genetic effects on cognitive impairment (CI) conditioned on genetic variants (SNPs) associated with systemic inflammation as measured by CRP and with plasma lipids using data from the Health and Retirement Study (HRS). SNP enrichment is observed for CI conditioned on the secondary phenotypes of plasma CRP and lipids. Fold enrichment of 100% - 800% was observed for increasingly stringent p-value thresholds for SNPs associated with CI conditional on plasma CRP, 80%-800% for Low-Density Lipoprotein (LDL) and 80% - 600% for total cholesterol (TC). Significant associations (FDR (q) ≤ 0.0

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