rs117240677 - LINC01148 - LINC02296
Magnitude 4.5 · 1 study on file
Reported associations
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Genome‐wide association of individual vulnerability with alcohol‐associated liver disease: A Korean genome and epidemiology study - Unknown journal (n.d.) · Unknown authors · PubMed 34387878
ABSTRACT: Abstract Background and aims The quantity of alcohol leading to alcohol‐associated liver disease (ALD) varies individually. Genetic backgrounds contributing to the divergence in individual susceptibility to alcohol‐induced liver damage have not been elucidated in detail. Approach and results Based on the Korean Genome and Epidemiology Study Health Examination (KoGES_HEXA) cohort data, 21,919 participants (40‐79 years old) were included and divided into cases and controls based on the ALD diagnostic criteria proposed by the American College of Gastroenterology. Data generated by a genome wide‐association study were analyzed using logistic regression to assess the risk of ALD development in nondrinkers, light drinkers, and heavy drinkers. We detected three loci, gamma‐glu
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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limiting or avoiding alcohol consumption Moderate
Genetic variant associated with increased alcohol-associated liver disease risk, even at light drinking levels
work with doctor to establish personal alcohol limits