rs117239007 - LINC00544 - LINC00365

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide Analysis of Motor Progression in Parkinson Disease - Unknown journal (n.d.) · Unknown authors · PubMed 37560120

  ABSTRACT: Background and Objectives The genetic basis of Parkinson disease (PD) motor progression is largely unknown. Previous studies of the genetics of PD progression have included small cohorts and shown a limited overlap with genetic PD risk factors from case-control studies. Here, we have studied genomic variation associated with PD motor severity and early-stage progression in large longitudinal cohorts to help to define the biology of PD progression and potential new drug targets. Methods We performed a GWAS meta-analysis of early PD motor severity and progression up to 3 years from study entry. We used linear mixed-effect models with additive effects, corrected for age at diagnosis, sex, and the first 5 genetic principal components to assess variability in axial, limb, and total Mo

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