rs11722856 - JAKMIP1, C4orf50

Magnitude 2.2 · 1 study on file

Reported associations

• Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition - Unknown journal (n.d.) · Unknown authors · PubMed 33426524

  ABSTRACT: Abstract Tau deposition is a key biological feature of Alzheimer's disease that is closely related to cognitive impairment. However, it remains poorly understood why certain individuals may be more susceptible to tau deposition while others are more resistant. The recent availability of in vivo assessment of tau burden through positron emission tomography provides an opportunity to test the hypothesis that common genetic variants may influence tau deposition. We performed a genome-wide association study of tau-positron emission tomography on a sample of 754 individuals over age 50 (mean age 72.4 years, 54.6% men, 87.6% cognitively unimpaired) from the population-based Mayo Clinic Study of Aging. Linear regression was performed to test nucleotide polymorphism associations with

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