rs11722777 - SORCS2

Magnitude 2.2 · 1 study on file

Reported associations

• GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population - Unknown journal (n.d.) · Unknown authors · PubMed 31345160

  ABSTRACT: Background Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey. Results Candidate genetic loci associated with habitual coffee consumption were searched within a discovery cohort (N = 6,264) and confirmed in a replication cohort (N = 5,975). Two loci achieved genome-wide significance (P < 5 × 10− 8) in a meta-analysis of the discovery and replication cohorts: an Asian population-specific 12q24 (rs79105258; P = 9.5 × 10− 15), which harbors CUX2, and 7p21 (rs10252701; P = 1.0 × 10− 14), in the upstream region of the aryl hydrocarbon receptor (AHR) gene, involved in caffeine meta

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.