rs11721971 - LINC02462 - EEF1A1P35
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic Associations of Chronotype in the Finnish General Population - Unknown journal (n.d.) · Unknown authors · PubMed 32579418
ABSTRACT: Individuals with a later chronotype (evening types) tend to have unhealthier behaviors and increased morbidity and mortality as compared with those with an earlier chronotype (morning types). However, the role of genetics in explaining evening types' adverse health and health behavior is unclear. Our aim was to study genetic associations of chronotype among 8433 Finns from the cross-sectional National FINRISK 2007 and 2012 studies. First, we studied associations between chronotype and 20 key clock genes with a candidate-gene approach and then performed a full genome-wide association study (GWAS) of chronotype. We also developed a genetic risk score (GRS) for chronotype based on 313 single nucleotide polymorphisms (SNPs) that have previously been associated with chronotype. Chro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic chronotype predisposition and optimization Moderate
G allele associated with evening chronotype; clinical discussion can identify sleep disorders, optimize medication timing, and plan workplace accommodation
Discuss sleep challenges, management strategies, and workplace accommodation options with physician
Lifestyle
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Align work and sleep schedule to evening chronotype Moderate
G allele strongly associated with evening chronotype; matching schedule to natural circadian preference may improve sleep quality, alertness, and daytime functioning
Explore flexible work scheduling; prioritize afternoon-evening for high-stakes work and exercise