rs11719409 - GPATCH11P1 - RNU6-1270P

Magnitude 2.0 · 1 study on file

Reported associations

• Surgical Necrotizing Enterocolitis in Extremely Premature Neonates is Associated with Genetic Variations in an Intergenic Region of Chromosome Eight - Pediatric research (2019) · Jilling T, Ambalavanan N, Cotten CM, Martin CA, Maheshwari A, Schibler K, Levy J, Page GP · PubMed 29538362

  ABSTRACT: Background Twin studies suggest that genetic factors may account for up to 50% increased risk for necrotizing enterocolitis (NEC), but genome-wide association studies (GWAS) for NEC are lacking. Methods Genotyping was done on Illumina BeadChip, followed by analysis using PLINK with logistic regression under an additive model. Results Among 751 extremely low birth weight (<1000g, >401g) neonates, 30 had surgical NEC. 261 single nucleotide polymorphisms (SNPs) showed association with NEC at P<0.05, of which 35 were significant at P<10−7. Minor allele(s) in a a cluster of SNPs spanning a 43 Kb region of chromosome 8 (8q23.3) conferred an odds ratio of 4.72 (95% CI 2.51-8.88) for elevated risk of NEC. Two smaller clusters on chromosome 14 and chromosome 11 exhibited P values 10−7

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