rs117191384 - RN7SKP15 - PTHLH

Magnitude 2.0 · 1 study on file

Reported associations

• A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers - iScience (2023) · Zhao X, Wu X, Xiao J, Zhang L, Hao Y, Xiao C, Zhang B, Li J, Jiang X · PubMed 37636041

  ABSTRACT: Summary Little is known regarding the long-term adverse effects of COVID-19 on female-specific cancers, nor the shared genetic influences underlying these conditions. We performed a comprehensive genome-wide cross-trait analysis to investigate the shared genetic architecture between COVID-19 (infection, hospitalization, and critical illness) with three female-specific cancers (breast cancer (BC), epithelial ovarian cancer (EOC), and endometrial cancer (EC)). We identified significant genome-wide genetic correlations with EC for both hospitalization ( = 0.19, p = 0.01) and critical illness ( = 0.29, p = 3.00 × 10−4). Mendelian randomization demonstrated no valid association of COVID-19 with any cancer of interest, except for suggestive associations of genetically predicte

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