rs11718509 - PBRM1
Magnitude 2.2 · 1 study on file
Reported associations
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New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 34294844
ABSTRACT: Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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migraine risk and prevention strategies High
PBRM1 rs11718509 is a genome-wide significant risk allele for migraine, particularly in women, affecting chromatin-remodeling pathways
Discuss migraine history and preventive options with healthcare provider
Screening
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migraine symptoms and headache patterns High
Risk allele carriers have increased genetic susceptibility to migraine, warranting proactive symptom tracking
Track headache frequency, intensity, triggers, and associated symptoms in a log to share with provider