Expressive

rs117173739 - FERD3L - POLR1F

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome‐wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores - Unknown journal (n.d.) · Unknown authors · PubMed 34989438

    ABSTRACT: Abstract Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization (MR) and horizontal pleiotropy analysis of S/DBP summary statistics from the UK Biobank (UKB)‐International Consortium for Blood Pressure (ICBP) (UKB‐ICBP) BP genome‐wide association study and construct a composite genetic risk score (GRS) by including pleiotropic variants. The composite GRS captures greater (1.11-3.26 fold) heritability for BP traits and increases (1.09‐ and 2.01‐fold) Nagelkerke's R 2 for hypertension and CVD. We replicated 118 novel BP horizontal pleiotropic variants including 18 novel BP loci using summary statistics from the Million Veteran Program (MVP) study

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce sodium intake Moderate

    Sodium restriction lowers blood pressure and reduces cardiovascular risk in genetically predisposed individuals.

    Limit sodium to less than 2300mg daily, aiming for 1500mg daily if tolerated.

Discuss with your doctor

  • personalized hypertension prevention plan Moderate

    Genetic predisposition warrants individualized cardiovascular risk assessment and management strategy.

Exercise

  • aerobic exercise Moderate

    Regular aerobic exercise reduces blood pressure and cardiovascular risk in those with genetic predisposition.

    150 minutes per week moderate intensity or 75 minutes vigorous intensity aerobic activity.

Lifestyle

  • stress reduction practices Moderate

    Chronic stress elevates blood pressure; stress management reduces cardiovascular risk.

    Practice daily stress reduction for 30 minutes: meditation, deep breathing, yoga, or similar relaxation.

Screening

  • blood pressure monitoring Moderate

    Genetic variant associated with higher blood pressure; monitoring enables early detection and intervention.

    Establish baseline blood pressure; monitor annually or per provider guidance.