Expressive

rs117171767 - SERPINA6

Magnitude 4.5 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Calcium from food sources Moderate

    Adequate calcium is essential for bone mineralization and strength, critical for fracture prevention

    Target 1000-1200 mg daily from dairy, leafy greens, fortified foods

Discuss with your doctor

  • Fall prevention and fracture risk reduction strategies Moderate

    Secondary prevention through fall avoidance is critical given genetic increased fracture susceptibility

Exercise

  • Weight-bearing and resistance exercise Moderate

    Mechanical loading through exercise stimulates bone formation and strengthens bone, preventing fractures

    150 minutes moderate activity weekly plus 2 days resistance training

Screening

  • Bone density screening (DEXA scan) Moderate

    SERPINA6 variant increases femur fracture risk through altered cortisol binding affecting bone metabolism

    Discuss timing with physician, typically 50-65 for women, 70+ for men

Supplements

  • Vitamin D supplementation and status Moderate

    Vitamin D is required for calcium absorption and bone mineralization, especially important given fracture risk

    Maintain 25-OH vitamin D 30-50 ng/mL; supplement 1000-2000 IU daily or per serum levels