rs117169751 - VPS37C - PGA3

Magnitude 2.0 · 1 study on file

Reported associations

• Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population - Science advances (2025) · Liu TY, Lu HF, Chen YC, Liao CC, Lin YJ, Yang JS, Liao WL, Lin WD, Chen SY, Huang YC, Lin WY, Liu YH, Hsu KC, Chang SS, Chen HD, Chou YP, Chang JG, Wang CH, Chang CT, Huang CM, Yeo KJ, Wang TY, Yeh CC, Chen JH, Huang CP, Lai HC, Chen RH, Lin HJ, Wu PY, Wang JY, Kuo CC, Cho DY, Tsai CH, Tsai FJ · PubMed 40465716

  ABSTRACT: We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for the Taiwanese Han population. Using a custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data to enable GWASs, phenome-wide association studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry and quality control filtering. GWASs covered 1085 traits, focusing on diseases prevalent in Taiwan such as type 2 diabetes, chronic kidney disease, gout, and alcoholic liver damage. PRSs were calculated for 238 traits, with the strongest associations observed in musculoskeletal disorders. Incorporating PRS into clinical practice

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