rs1171633 - SLC16A9

Magnitude 4.5 · 1 study on file

Reported associations

• An Extreme Phenotype Approach Suggests Taste Transduction Pathway for Carotid Plaque in a Multi-Ethnic Cohort - Unknown journal (n.d.) · Unknown authors · PubMed 32811377

  ABSTRACT: Background and Purpose: Carotid plaque is a heritable trait and a strong predictor of vascular events. Several loci have been identified for carotid plaque, however, studies in minority populations are lacking. Within a multi-ethnic cohort, we have identified individuals with extreme total carotid plaque area (TCPA), i.e. higher or lower TCPA than expected based on traditional vascular risk factors (age, sex, smoking, diabetes, hypertension, etc). We hypothesized that these individuals are enriched with genetic variants accounting for the plaque burden that cannot be explained by traditional vascular risk factors. Herein, we sought to identify the genetic basis for TCPA using the multi-ethnic cohort. Methods: 340 participants (170 from each extreme group) from three race/ethnic g

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