rs117149828 - ULK4
Magnitude 4.5 · 1 study on file
Reported associations
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Genome‐wide association of individual vulnerability with alcohol‐associated liver disease: A Korean genome and epidemiology study - Unknown journal (n.d.) · Unknown authors · PubMed 34387878
ABSTRACT: Abstract Background and aims The quantity of alcohol leading to alcohol‐associated liver disease (ALD) varies individually. Genetic backgrounds contributing to the divergence in individual susceptibility to alcohol‐induced liver damage have not been elucidated in detail. Approach and results Based on the Korean Genome and Epidemiology Study Health Examination (KoGES_HEXA) cohort data, 21,919 participants (40‐79 years old) were included and divided into cases and controls based on the ALD diagnostic criteria proposed by the American College of Gastroenterology. Data generated by a genome wide‐association study were analyzed using logistic regression to assess the risk of ALD development in nondrinkers, light drinkers, and heavy drinkers. We detected three loci, gamma‐glu
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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alcohol consumption Moderate
rs117149828 is associated with increased susceptibility to alcohol-associated liver disease, even at light drinking levels
eliminate or minimize alcohol intake
Discuss with your doctor
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rs117149828 genetic risk and alcohol consumption Moderate
rs117149828 variants increase genetic susceptibility to alcohol-associated liver disease; professional risk assessment helps personalize prevention strategies
Screening
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liver function tests Moderate
rs117149828 carriers have increased risk for alcohol-associated liver disease; regular monitoring enables early detection of liver dysfunction
baseline liver panel (AST, ALT, alkaline phosphatase, bilirubin, albumin); repeat every 1-2 years