rs11713169 - NLGN1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis - Unknown journal (n.d.) · Unknown authors · PubMed 25628336

  ABSTRACT: Roughly one in three individuals is highly susceptible to motion sickness and yet the underlying causes of this condition are not well understood. Despite high heritability, no associated genetic factors have been discovered. Here, we conducted the first genome-wide association study on motion sickness in 80 494 individuals from the 23andMe database who were surveyed about car sickness. Thirty-five single-nucleotide polymorphisms (SNPs) were associated with motion sickness at a genome-wide-significant level (P < 5 × 10−8). Many of these SNPs are near genes involved in balance, and eye, ear and cranial development (e.g. PVRL3, TSHZ1, MUTED, HOXB3, HOXD3). Other SNPs may affect motion sickness through nearby genes with roles in the nervous system, glucose homeostasis or hypoxia.

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