rs11712309 - NXPE3
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 - Unknown journal (n.d.) · Unknown authors · PubMed 37198478
ABSTRACT: Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown to be highly efficient for discovery of genetic associations. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized COVID-19 prevention strategies Moderate
rs11712309-T is associated with increased COVID-19 hospitalization risk; medical guidance tailored to your genotype may reduce severity.
Lifestyle
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COVID-19 vaccination status Moderate
rs11712309-T is associated with 10% increased risk of COVID-19 hospitalization in a genome-wide study of 2.97 million individuals.
maintain current COVID-19 vaccination and booster schedule per health authority guidelines
Screening
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early detection of COVID-19 infection Moderate
rs11712309-T increases COVID-19 hospitalization risk; early detection allows timely intervention.
test promptly if respiratory symptoms develop; monitor oxygen levels and breathing if infected