rs11711203 - TP63

Magnitude 2.2 · 1 study on file

Reported associations

• Joint Genome-Wide Association Analyses Identified 49 Novel Loci For Age at Natural Menopause. - The Journal of clinical endocrinology and metabolism (2021) · Zhang L, Wei XT, Niu JJ, Lin ZX, Xu Q, Ni JJ, Zhang WL, Han BX, Yan SS, Feng GJ, Zhang H, Yang XL, Zhang ZJ, Hai R, Ren HG, Zhang F, Pei YF · PubMed 34050765

  Age at natural menopause (ANM) is an important index for women's health. Either early or late ANM is associated with a series of adverse outcomes later in life. Despite being an inheritable trait, its genetic determinant has not yet been fully understood. Aiming to better characterize the genetic architecture of ANM, we conducted genome-wide association study (GWAS) meta-analyses in European-specific as well as trans-ancestry samples by using GWAS summary statistics from the following 3 large studies: the Reproductive Genetics Consortium (ReproGen; N = 69 626), the UK Biobank cohort (UKBB; N = 111 593) and the BioBank Japan Project (BBJ; N = 43 861), followed by a series of bioinformatical assessments and functional annotations. By integrating the summary statistics from the 3 GWAS of up t

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.