rs117107596 - NTN1

Magnitude 2.0 · 1 study on file

Reported associations

• The BS variant of C4 protects against age-related loss of white matter microstructural integrity. - Brain : a journal of neurology (2022) · Traylor M, Malik R, Gesierich B, Dichgans M · PubMed 34358307

  Age-related loss of white matter microstructural integrity is a major determinant of cognitive decline, dementia and gait disorders. However, the mechanisms and molecular pathways that contribute to this loss of integrity remain elusive. We performed a genome-wide association study of white matter microstructural integrity as quantified by diffusion MRI metrics (mean diffusivity and fractional anisotropy) in up to 31 128 individuals from UK Biobank (age 45-81 years) based on a two degrees of freedom (2df) test of single nucleotide polymorphism (SNP) and SNP × Age effects. We identified 18 loci that were associated at genome-wide significance with either mean diffusivity (n = 16) or fractional anisotropy (n = 6). Among the top loci was a region on chromosome 6 encoding the human major hist

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