rs11710563 - ROBO1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery. - Atherosclerosis (2017) · Pott J, Burkhardt R, Beutner F, Horn K, Teren A, Kirsten H, Holdt LM, Schuler G, Teupser D, Loeffler M, Thiery J, Scholz M · PubMed 28282560

  Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. After investigating the reliability of plaque detection, we performed a genome-wide meta-association study in two independent cohorts (LIFE-Adult, n = 4037 and LIFE-Heart, n = 3152) for carotid plaque score (PS), defined as the sum of the plaque load of common carotid artery and carotid bulb. Further, we analyzed whether previously reported CAD and stroke loci were also associated with PS. We identified two loci with genome-wide significance for PS. One locus is the known CAD-locus at chromosome 9p21 (l

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