rs11710497 - SLC6A1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood. - Twin research and human genetics : the official journal of the International Society for Twin Studies (2015) · Adkins DE, Clark SL, Copeland WE, Kennedy M, Conway K, Angold A, Maes H, Liu Y, Kumar G, Erkanli A, Patkar AA, Silberg J, Brown TH, Fergusson DM, Horwood LJ, Eaves L, van den Oord EJ, Sullivan PF, Costello EJ · PubMed 26081443

  The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to search for common genetic variants predicting developmental trajectories of alcohol consumption. Comparable psychiatric evaluations measuring alcohol consumption were collected in three longitudinal community samples (N=2,126, obs=12,166). Consumption-repeated measurements spanning adolescence and early adulthood were analyzed using linear mixed models, estimating individual consumption trajectories, which were then tested for association with Illumina 660W-Quad genotype data (866,099 SNPs after imputation and QC). Association results were combined across samp

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