rs1171043882 - ZSWIM5 - HPDL
Magnitude 2.2 · 1 study on file
Reported associations
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Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923
ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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LDL cholesterol levels Moderate
This variant is associated with increased LDL cholesterol in population cohorts.
Check LDL panel annually or per healthcare provider guidance.
Discuss with your doctor
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Genetic predisposition to elevated LDL cholesterol Moderate
Genetic variant associated with higher circulating LDL cholesterol levels.
Lifestyle
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Cardiovascular-healthy lifestyle pattern Moderate
Elevated LDL from this variant increases atherosclerosis and cardiovascular disease risk; lifestyle factors can help manage cholesterol.
Regular aerobic exercise (150 min/week), maintain healthy weight, avoid smoking.