rs11710258 - SCHIP1, IQCJ-SCHIP1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci - Unknown journal (n.d.) · Unknown authors · PubMed 30837455
ABSTRACT: Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461,106) heritability is estimated at 8.2% (95% CI: 6.4%, 9.9%). This study finds 97 variants which alter the odds of developing non-specific mouth ulcers and replicate these in an independent cohort (n = 355,744) (lead variant after meta-analysis: rs76830965, near IL12A, OR 0.72 (95% CI: 0.71, 0.73); P = 4.4e−483). Additional effect estimates from three independent cohorts with more specific phenotyping and specific study characteristics support many of these findings. In s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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mouth ulcer frequency and severity Moderate
Genetic variant rs11710258 is associated with increased susceptibility to mouth ulcers in large-scale population studies
Track monthly; note patterns, duration, and severity; discuss with provider if frequent or severe