Expressive

rs11706494 - NXPE3

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 - Unknown journal (n.d.) · Unknown authors · PubMed 37198478

    ABSTRACT: Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown to be highly efficient for discovery of genetic associations. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic risk assessment for COVID-19 severity High

    rs11706494-A allele is genome-wide significantly associated with 1.1-fold increased odds of critical illness if SARS-CoV-2 infected

    review personalized COVID-19 prevention strategy and discuss early treatment options if exposed or symptomatic

Lifestyle

  • enhanced COVID-19 prevention measures High

    rs11706494-A carriers have 1.1-fold higher odds of critical illness if infected with SARS-CoV-2; prevention reduces infection risk

    use masks in crowded settings, improve home ventilation, isolate when symptomatic, maintain vaccination

Screening

  • early COVID-19 symptom recognition High

    rs11706494-A carriers progress to critical illness more readily if infected; prompt intervention may mitigate severity

    seek immediate medical evaluation for respiratory symptoms, fever, or fatigue if COVID-19 suspected