rs117060920 - IER3IP1 - SKOR2

Magnitude 2.2 · 1 study on file

Reported associations

• Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population. - Biological trace element research (2022) · Guo D, Zhou Y, Wei X, Zhang S, Jin T, Zhang Y, Lin M, Zhou X, Xie Y, He C, Lin Q, He P, Ding Y · PubMed 34417961

  Mineral elements (copper (Cu), zinc (Zn), calcium (Ca), magnesium (Mg), iron (Fe)) play important biological roles in enzymes, hormones, vitamins, and normal metabolism. The deficiency of mineral elements can lead to abnormal physiological functions. And some elements (such as lead (Pb)) are harmful to the body. We aim to identify genetic loci which can influence the serum levels of mineral elements (Cu, Zn, Ca, Mg, Fe, and Pb). Genotyping was performed using Applied Biosystems Axiom™ PMDA in 587 individuals, and 6,423,076 single-nucleotide polymorphisms (SNPs) were available for the genome-wide association study (GWAS) analysis. The association between genotype and phenotype was analyzed using mixed linear regression (additive genetic model) adjusting by age and gender combined with ide

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