rs11705307 - NHIP - RPL35P8

Magnitude 2.2 · 1 study on file

Reported associations

• 3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies - Unknown journal (n.d.) · Unknown authors · PubMed 33983923

  ABSTRACT: The analysis of contemporary genomic data typically operates on one-dimensional phenotypic measurements (e.g. standing height). Here we report on a data-driven, family-informed strategy to facial phenotyping that searches for biologically relevant traits and reduces multivariate 3D facial shape variability into amendable univariate measurements, while preserving its structurally complex nature. We performed a biometric identification of siblings in a sample of 424 children, defining 1,048 sib-shared facial traits. Subsequent quantification and analyses in an independent European cohort (n = 8,246) demonstrated significant heritability for a subset of traits (0.17-0.53) and highlighted 218 genome-wide significant loci (38 also study-wide) associated with facial variation shared

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