rs11705126 - LINC02554 - CPMER
Magnitude 2.2 · 1 study on file
Reported associations
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Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans - Unknown journal (n.d.) · Unknown authors · PubMed 25811787
ABSTRACT: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese stra
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum uric acid level Moderate
rs11705126 C allele is associated with elevated serum urate levels, which increases risk of gout and renal complications
Obtain baseline serum uric acid, recheck annually or as clinically indicated
Discuss with your doctor
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serum uric acid management strategy Moderate
rs11705126 C allele is associated with elevated serum urate levels, which increases risk of gout, arthritis, and cardiovascular disease
Discuss baseline urate level and prevention strategies at next visit