rs117046683 - TRBV29-1 - PRSS1

Magnitude 2.2 · 1 study on file

Reported associations

• Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization - Unknown journal (n.d.) · Unknown authors · PubMed 38491158

  ABSTRACT: Previous studies found lipid levels, especially triglycerides (TG), are associated with acute pancreatitis, but their causalities and bi-directions were not fully examined. We determined whether abnormal levels of TG, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) are precursors and/or consequences of acute pancreatitis using bidirectional two-sample Mendelian randomization (MR) with two non-overlapping genome-wide association study (GWAS) summary statistics for lipid levels and acute pancreatitis. We found phenotypic associations that both higher TG levels and lower HDL-C levels contributed to increased risk of acute pancreatitis. Our GWAS meta-analysis of acute pancreatitis identified seven independent signals. Genetically predicte

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