Expressive

rs1170109 - DGKH

Magnitude 2.2 · 2 studies on file

Reported associations

  • The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels. - Psychoneuroendocrinology (2018) · Neumann A, Direk N, Crawford AA, Mirza S, Adams H, Bolton J, Hayward C, Strachan DP, Payne EK, Smith JA, Milaneschi Y, Penninx B, Hottenga JJ, de Geus E, Oldehinkel AJ, van der Most PJ, de Rijke Y, Walker BR, Tiemeier H · PubMed 28843169

    Cortisol is an important stress hormone affected by a variety of biological and environmental factors, such as the circadian rhythm, exercise and psychological stress. Cortisol is mostly measured using blood or saliva samples. A number of genetic variants have been found to contribute to cortisol levels with these methods. While the effects of several specific single genetic variants is known, the joint genome-wide contribution to cortisol levels is unclear. Our aim was to estimate the amount of cortisol variance explained by common single nucleotide polymorphisms, i.e. the SNP heritability, using a variety of cortisol measures, cohorts and analysis approaches. We analyzed morning plasma (n=5705) and saliva levels (n=1717), as well as diurnal saliva levels (n=1541), in the Rotterdam Study

  • Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 36329257

    ABSTRACT: To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative traits. Extensive analysis on glycaemic phenotypes (T2D, fasting glucose and HbA1c) was performed and identified 115 significant loci with four novel genetic variants (HACL1, RAD21, ASH1L and GAK). Transcriptomics data also strengthen the relevancy of the findings to metabolic disorders, thus contributing to better understanding of pathogenesis. In addition, genetic risk sc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • manage sodium, calcium, and oxalate intake High

    rs1170109 increases kidney stone risk; dietary sodium and oxalate-calcium balance affect urinary saturation and lithogenesis

    limit sodium <2300 mg/day, maintain calcium intake 1000-1200 mg/day, moderate high-oxalate foods

Lifestyle

  • maintain adequate hydration for kidney stone prevention High

    rs1170109 associated with increased kidney stone risk; dilute urine reduces stone formation

    drink 2-2.5 liters water daily, increase with exercise or heat exposure

Screening

  • baseline saliva cortisol measurement Moderate

    rs1170109 T allele associated with elevated baseline cortisol; testing characterizes individual phenotype for HPA axis function

    discuss cortisol testing with provider if no recent baseline measurement available