Expressive

rs116986845 - SNRPGP17 - YPEL2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

  • Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels - Unknown journal (n.d.) · Unknown authors · PubMed 35050183

    ABSTRACT: Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an organism and the mechanisms that control key physiological processes involved in health and disease. Here we report the results of a genome-wide association study of 722 circulating metabolite levels in 8809 subjects of European origin, providing both breadth and depth. These analyses identified 202 unique genomic regions whose variations are associated with the circulating levels of 478 different metabolites. Replication with a subset of 208 metabolites that were available in an independent dataset for a cohort of 1768 European subjects confirmed the robust associations, including 74 novel genomic regions not associated with any metabolites in previous works. This study enhances our knowl

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Low glycemic index dietary pattern Moderate

    Low GI foods reduce postprandial glucose spikes and support HbA1c reduction in individuals with elevated baseline glucose.

    Prioritize whole grains, legumes, non-starchy vegetables; limit refined carbohydrates and added sugars.

Exercise

  • Regular aerobic exercise for glycemic control Moderate

    Aerobic exercise improves insulin sensitivity and glucose tolerance in individuals with elevated HbA1c and metabolic risk.

    150 minutes moderate intensity per week or 75 minutes vigorous intensity per week.

Screening

  • Baseline HbA1c and fasting glucose Moderate

    Variant associated with elevated HbA1c levels (effect=0.050 per risk allele), indicating increased diabetes risk.

    Baseline testing followed by annual monitoring; consider more frequent if family history or weight gain occur.