Expressive

rs11695484 - UGT1A9, UGT1A8, UGT1A7, UGT1A3, UGT1A5, UGT1A6, UGT1A10, UGT1A4

Magnitude 2.0 · 3 studies on file

Reported associations

  • Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort. - Sleep medicine (2021) · Chu X, Liu L, Ye J, Wen Y, Li P, Cheng B, Cheng S, Zhang L, Qi X, Ma M, Liang C, Kafle OP, Wu C, Wang S, Wang X, Ning Y, Zhang F · PubMed 34343768

    We aim to explore the mechanism of relationship between insomnia and liver metabolism by examining the gene × insomnia interactions. Individual level genotypic and phenotypic data were obtained from the UK Biobank cohort. Regression analysis was first conducted to test the association of insomnia with plasma total bilirubin (TBil; n = 186,793), direct bilirubin (DBil; n = 159,854) and total protein (TP; n = 171,574) in UK Biobank cohort. Second, genome-wide gene-environment interaction study (GWGEIS) was conducted by PLINK 2.0, and FUMA platform was used to identify enriched pathway terms. In UK Biobank cohort, we found that TP (P < 2.00 × 10 ), DBil (P = 1.72 × 10 ) and TBil (P = 3.38 × 10 ) were significantly associated with insomnia. GWGEIS of both DBil and TBil

  • Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine - Unknown journal (n.d.) · Unknown authors · PubMed 37277652

    ABSTRACT: The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the transporters NaDC3 (SLC13A3) and ASBT (S

  • Genome-wide Association Study of Tenofovir Pharmacokinetics and Creatinine Clearance in AIDS Clinical Trials Group Protocol A5202 - Unknown journal (n.d.) · Unknown authors · PubMed 26148204

    ABSTRACT: Background Tenofovir disoproxil fumarate (TDF) causes kidney toxicity in some patients. We performed genome-wide analyses to identify associations with plasma tenofovir clearance and change in creatinine clearance (CrCl) during the first 6 months after initiating therapy among subjects randomized to TDF/emtricitabine-containing regimens in AIDS Clinical Trials Group protocol A5202. Methods Pharmacokinetic analyses involved 501 subjects randomized to the tenofovir arm. The CrCl analyses involved 1096 subjects, including 548 control subjects randomized to abacavir-containing regimens. All had been randomized to also receive atazanavir/ritonavir or efavirenz. Multivariable linear regression and generalized least squares models tested for associations between polymorphisms and tenofo

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