Expressive

rs116953263 - LINC01976 - PYY

Magnitude 2.2 · 1 study on file

Reported associations

  • Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. - American journal of human genetics (2018) · Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F · PubMed 29304378

    Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been identified as associated with BMD. To investigate the genetic determinants of TB-BMD variation along the life course and test for age-specific effects, we performed a meta-analysis of 30 genome-wide association studies (GWASs) of TB-BMD including 66,628 individuals overall and divided across five age strata, each spanning 15 years. We identified variants associated with TB-BMD at 80 loci, of which 36 have not been previously identified; overall, they explain approximately 10% of the TB-BMD vari

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Adequate dietary calcium Moderate

    Calcium is essential for bone mineralization and helps support bone density in carriers of the BMD-lowering rs116953263-T allele

    1000-1200 mg daily from food sources or supplementation

Exercise

  • Weight-bearing exercise for bone health Moderate

    Load-bearing exercise stimulates bone formation and counters genetic predisposition to lower bone mineral density

    150 minutes moderate intensity per week, or resistance training 2-3 times weekly

Screening

  • Bone mineral density screening Moderate

    rs116953263-T allele is associated with lower bone mineral density (GWAS p=2.00e-9, effect=-0.092 per allele), suggesting increased osteoporosis risk

    Obtain baseline DEXA scan; discuss timing with physician based on age and other risk factors

Supplements

  • Vitamin D supplementation Moderate

    Vitamin D is required for calcium absorption and regulates bone turnover; supports bone health in those with genetic lower BMD

    1000-2000 IU daily, or adjust based on serum 25-OH vitamin D levels (target 30-50 ng/mL)