Expressive

rs11694327 - KCNK3

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis - Unknown journal (n.d.) · Unknown authors · PubMed 40075078

    ABSTRACT: Sarcoidosis is a complex inflammatory disease with a strong genetic component. Here, we perform a genome-wide association study in 9755 sarcoidosis cases to identify risk loci and map associated genes. We then use transcriptome-wide association studies and enrichment analyses to explore pathways involved in sarcoidosis and use Mendelian randomization to examine associations with modifiable factors and circulating biomarkers. We identify 28 genomic loci associated with sarcoidosis, with the C1orf141-IL23R locus showing the largest effect size. We observe gene expression patterns related to sarcoidosis in the spleen, whole blood, and lung, and highlight 75 tissue-specific genes through transcriptome-wide association studies. Furthermore, we use enrichment analysis to establish key

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Moderate-to-vigorous physical activity Low

    Mendelian randomization suggests genetically predicted physical activity is associated with reduced sarcoidosis risk

    Aim for 150+ minutes moderate-intensity or 75+ minutes vigorous-intensity weekly activity

Lifestyle

  • Body mass index maintenance to reduce sarcoidosis risk Moderate

    Genetically predicted BMI is causally associated with 1.26-fold increased sarcoidosis risk per SD increase

    Aim for BMI 18.5-24.9; weight management if currently overweight or obese

Screening

  • Sarcoidosis risk and baseline health assessment Moderate

    KCNK3 rs11694327 C allele is associated with increased genetic susceptibility to sarcoidosis, a systemic inflammatory disorder affecting lungs and other organs

    Discuss sarcoidosis risk assessment and appropriate screening with healthcare provider