Expressive

rs11693526 - LINC01830

Magnitude 2.2 · 2 studies on file

Reported associations

  • Polygenic Hyperlipidemias and Coronary Artery Disease Risk - Unknown journal (n.d.) · Unknown authors · PubMed 32154731

    ABSTRACT: Supplemental Digital Content is available in the text. Background: Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk. Methods: We derived polygenic risk scores (PRSs) with ≈6M variants separately for LDL-C and TG with weights from a UK Biobank-based genome-wide association study with ≈324K samples. We evaluated the impact of polygenic hypercholesterolemia and hypertriglyceridemia to lipid levels in 27 039 individuals from the National FINRISK Study

  • Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32203549

    ABSTRACT: Background Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic instruments for lipoprotein lipid traits implemented through multivariable Mendelian randomisation (MR), we sought to compare their causal roles in the aetiology of CHD. Methods and findings We conducted a genome-wide association study (GWAS) of circulating non-fasted lipoprotein lipid traits in the UK Biobank (UKBB) for low-density lipoprotein (LDL) cholesterol, triglycerides, and apolipoprotein B to identify lipid-associated single nucleotide polymorphisms (SNPs). Using data from CARDIoGRAMplusC4D for CHD (consisting of 60,801 cases and 123,504 controls), we per

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • apolipoprotein B and LDL cholesterol levels High

    The T allele of rs11693526 is associated with elevated apolipoprotein B and LDL cholesterol.

    Check baseline; then every 1-2 years or annually if results are elevated

Diet

  • heart-healthy diet emphasizing fiber and unsaturated fats Moderate

    Dietary changes can help manage elevated ApoB and LDL cholesterol associated with the T allele.

    Emphasize whole grains, unsaturated fats, fish, legumes, and vegetables

Discuss with your doctor

  • genetic predisposition to elevated ApoB and LDL cholesterol High

    Carriers of the T allele have genetically-elevated ApoB and LDL, which increase cardiovascular risk.