rs116928232 - LIPA
Magnitude 2.2 · 1 study on file
Reported associations
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Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses - Unknown journal (n.d.) · Unknown authors · PubMed 34226706
ABSTRACT: Exome association studies to date have generally been underpowered to systematically evaluate the phenotypic impact of very rare coding variants. We leveraged extensive haplotype sharing between 49,960 exome-sequenced UK Biobank participants and the remainder of the cohort (total N~500K) to impute exome-wide variants with accuracy R2>0.5 down to minor allele frequency (MAF) ~0.00005. Association and fine-mapping analyses of 54 quantitative traits identified 1,189 significant associations (P<5 x 10−8) involving 675 distinct rare protein-altering variants (MAF<0.01) that passed stringent filters for likely causality. Across all traits, 49% of associations (578/1,189) occurred in genes with two or more hits; follow-up analyses of these genes identified allelic series containing up
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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anti-inflammatory foods rich in omega-3 fatty acids Moderate
LIPA SNP associates with elevated CRP; anti-inflammatory dietary patterns reduce CRP and cardiovascular risk
include fatty fish 2-3x weekly, abundant vegetables, minimize refined carbohydrates and processed foods
Exercise
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regular aerobic exercise Moderate
LIPA rs116928232 risk allele associates with elevated C-reactive protein; aerobic exercise reduces CRP and cardiovascular risk
150 minutes per week of moderate-intensity aerobic activity
Screening
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C-reactive protein levels Moderate
LIPA rs116928232 associates with elevated CRP; periodic monitoring helps assess cardiovascular risk
baseline CRP test, repeat annually or as clinically indicated