rs11692742 - CAMKMT - LINC01833
Magnitude 2.2 · 1 study on file
Reported associations
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Participation bias in the UK Biobank distorts genetic associations and downstream analyses - Unknown journal (n.d.) · Unknown authors · PubMed 37106081
ABSTRACT: While volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely representative of their target population. To evaluate the impact of selective participation, here we derived UK Biobank participation probabilities on the basis of 14 variables harmonized across the UK Biobank and a representative sample. We then conducted weighted genome-wide association analyses on 19 traits. Comparing the output from weighted genome-wide association analyses (neffective = 94,643 to 102,215) with that from standard genome-wide association analyses (n = 263,464 to 283,749), we found that increasing representativeness led to changes in SNP effect sizes and identified novel SNP associations for 12 traits. While
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to increased alcohol consumption Moderate
The A allele at rs11692742 is associated with higher frequency of weekly alcohol consumption, suggesting a genetic predisposition that may influence drinking patterns and tolerance.
Discuss personal alcohol consumption patterns with your healthcare provider
Lifestyle
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Weekly alcohol consumption frequency and patterns Moderate
Genetic predisposition (A allele) associated with increased baseline drinking frequency; monitoring helps maintain awareness and control over personal consumption.
Track weekly alcohol intake, review against personal goals, and adjust as needed