Expressive

rs116918983 - SHISA9 - TMF1P1

Magnitude 2.2 · 1 study on file

Reported associations

  • Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits - Unknown journal (n.d.) · Unknown authors · PubMed 35121771

    ABSTRACT: The expanding use of the phenome-wide association study (PheWAS) faces challenges in the context of using International Classification of Diseases billing codes for phenotype definition, imbalanced study population ethnicity, and constrained application of the results in research. We performed a PheWAS utilizing 136 deep phenotypes corroborated by comprehensive health check-ups in a Korean population, along with trans-ethnic comparisons through using the UK Biobank and Biobank Japan Project. Meta-analysis with Korean and Japanese population was done. The PheWAS associated 65 phenotypes with 14,101 significant variants (P < 4.92 × 10-10). Network analysis, visualization of cross-phenotype mapping, and causal inference mapping with Mendelian randomization were conducted.

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate dietary calcium Moderate

    Dietary calcium binds oxalate in the intestinal lumen, reducing oxalate absorption and urinary excretion

    Maintain 1000-1200 mg daily from food sources; avoid excess calcium supplements

  • excessive animal protein Moderate

    High animal protein diet increases urinary uric acid and calcium, raising stone-forming substance concentration

    Limit red meat to 1-2 servings weekly; moderate poultry and fish intake

  • high sodium intake Moderate

    Dietary sodium increases urinary calcium excretion, raising supersaturation and stone-forming substance concentration

    Limit to less than 2300 mg sodium daily; emphasize fresh foods over processed items

Lifestyle

  • water intake for kidney stone prevention Moderate

    Increased urine volume dilutes urinary stone-forming solutes, reducing saturation and crystallization risk

    Target 2.5-3 liters daily; adjust for climate, exercise, and pale urine color

Screening

  • kidney stone screening and monitoring Moderate

    Genetic variant rs116918983 increases kidney stone formation risk; early detection enables preventive intervention

    Consider baseline renal ultrasound or CT; discuss symptom monitoring and follow-up plan with physician