Expressive

rs1169151 - LINC00609, PTCSC3

Magnitude 2.2 · 3 studies on file

Reported associations

  • Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk - Unknown journal (n.d.) · Unknown authors · PubMed 36508215

    ABSTRACT: Key Points Question Is a healthy lifestyle associated with thyroid cancer risk, and could it attenuate the influence of genetic variants on thyroid cancer? Findings In this cohort study that included 423 patients with incident thyroid cancer and 264 533 individuals without thyroid cancer, adherence to a healthier lifestyle attenuated the negative association of genetic factors with the risk of thyroid cancer in those of European descent. Participants with both a high polygenic risk score and an unfavorable lifestyle had the highest risk of thyroid cancer. Meaning The findings of this study highlight the potential of lifestyle interventions to reduce the risk of thyroid cancer, even in those at high genetic risk. Importance Genetic and lifestyle factors are related to thyroid ca

  • Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness - Unknown journal (n.d.) · Unknown authors · PubMed 29313844

    ABSTRACT: Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10−8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength o

  • Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies - Unknown journal (n.d.) · Unknown authors · PubMed 39266554

    ABSTRACT: Maintaining normal thyroid function is crucial in pregnancy, yet thyroid dysfunction and the presence of thyroid peroxidase antibodies (TPOAb) affect 0.5% to 18% of pregnant women. Here, we conducted a genome-wide association study (GWAS) of eight thyroid traits, including two thyroid-related hormones, four thyroid dysfunctions, and two thyroid autoimmunity measurements among 85,421 Chinese pregnant women to investigate the genetic basis of thyroid function during pregnancy. Our study identified 176 genetic loci, including 125 previously unknown genome-wide associations. Joint epidemiological and Mendelian randomization analyses revealed significant associations between the gestational thyroid phenotypes and gestational complications, birth outcomes, and later-age health outcomes

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