rs11691026 - LINC01822 - RN7SL117P
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex. - EBioMedicine (2023) · Sofer T, Kurniansyah N, Murray M, Ho YL, Abner E, Esko T, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ · PubMed 36989840
Genome-wide association studies (GWAS) for obstructive sleep apnoea (OSA) are limited due to the underdiagnosis of OSA, leading to misclassification of OSA, which consequently reduces statistical power. We performed a GWAS of OSA in the Million Veteran Program (MVP) of the U.S. Department of Veterans Affairs (VA) healthcare system, where OSA prevalence is close to its true population prevalence. We performed GWAS of 568,576 MVP participants, stratified by biological sex and by harmonized race/ethnicity and genetic ancestry (HARE) groups of White, Black, Hispanic, and Asian individuals. We considered both BMI adjusted (BMI-adj) and unadjusted (BMI-unadj) models. We replicated associations in independent datasets, and analysed the heterogeneity of OSA genetic associations across HARE and sex
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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sleep quality and weight management Moderate
Modifiable factors like weight and sleep hygiene can influence OSA severity; monitoring these supports overall sleep health.
Maintain healthy weight; optimize sleep hygiene; consider sleep position modifications if OSA-related symptoms develop
Screening
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obstructive sleep apnea risk assessment Moderate
Variant rs11691026 in LINC01822 is associated with increased obstructive sleep apnea risk based on genome-wide association analysis.
Discuss with physician about OSA screening options; consider sleep study if symptoms are present